How Long Is Botox Good For After Reconstitution
How Long Is Botox Good For After Reconstitution Botulinum toxin, commonly recognized as Botox, is a household name in aesthetic medicine. It’s employed to address various conditions, including:
- Temporarily smoothing out facial wrinkles and lines
- Treating hyperhidrosis, a condition characterized by excessive sweating
- Managing cervical dystonia, marked by severe contractions in neck and shoulder muscles
- Alleviating chronic migraines
- Controlling overactive bladders
One prevalent query about Botox is, “Does Botox require refrigeration?” In this article, we’ll address this question and other concerns that often preoccupy cosmetic healthcare practitioners and their patients.
Does Botox Need Refrigeration?
Ensuring the safety and efficacy of Botox necessitates storing the drug within a specific temperature range. As per Allergan, the manufacturer of Botox, vials should be maintained in refrigerators at temperatures ranging from 2°C to 8°C. Achieving this range mandates the use of dedicated medical refrigerators equipped with cutting-edge thermometers powered by smart technology. These thermometers continually monitor the refrigerator’s interior temperature and the temperature of the stored products. They are designed to detect any deviation from the prescribed temperature range, whether it’s a drop or rise, and trigger an alarm to draw attention to this variation. This allows for timely intervention to prevent temperature-related damage to your Botox.
The Importance of Proper Botox Storage
While it’s vital to store Botox within the recommended temperature range, it’s equally crucial to store the drug correctly. Although medical refrigerators are equipped to maintain the specific temperature ranges required, adhering to these storage tips can help preserve your products in usable conditions for extended periods, up to four weeks:
- Leave approximately 1cm of space between Botox boxes in the refrigerator.
- Ensure the boxes do not come into contact with the fridge’s sides or back, as this can lead to freezing.
- Avoid filling your medical refrigerator beyond 75% capacity.
- Keep Botox vials in their packaging to shield them from light, particularly if your refrigerator features a glass door.
- Establish a daily monitoring and logging routine for the refrigerator’s temperature to promptly identify any deviations from the required range.
Read More : What Happens If You Lay Down After Botox
Does Unreconstituted Botox Need Refrigeration?
Allergan recommends refrigerating unopened Botox vials within the temperature range of 2°C to 8°C for up to 36 months (for 100U vials) and up to 24 months (for 200U vials). However, the company has also confirmed that the drug remains stable even after being kept at room temperature for up to five days. This means you need not worry about a loss of potency or adverse side effects if your Botox was left unrefrigerated for less than five days.
But what if the drug is exposed to extreme conditions during shipping? Does it remain stable? Research conducted by L. Parraga et al. delved into these questions. They examined product information and engaged manufacturers in discussions. Their findings revealed that Botulinum toxin remains stable at 25°C for 14 days and at 30°C for seven days. This is excellent news for cosmetic health practitioners who no longer need to discard their products due to delayed refrigeration or unexpected refrigerator malfunctions. The product remains just as effective as refrigerated ones, preserving your bottom line.
How Long Can Botox Be Out of the Refrigerator?
Allergan has confirmed that Botox can safely remain out of the refrigerator for up to five days at room temperature. Moreover, studies have demonstrated that reconstituted Botox can be used for more extended periods than recommended. So, if scheduling challenges arise, you can safely utilize reconstituted Botox for several days or even weeks after reconstitution. Its effectiveness remains consistent, with results lasting just as long as freshly reconstituted Botox.
In comparing the effectiveness of freshly reconstituted Botox solutions with those aged for two hours, six days, one week, and four weeks, researchers found statistically similar results. They administered these solutions to volunteers, injecting both fresh and aged solutions into the extensor dithorium brevis muscles of their feet. The two-hour-old solution produced identical effects to the four-week-old one, maintaining the intended effects for the same duration.
Additional studies demonstrated that Botox solutions aged up to 43 days remained effective, with similar results compared to freshly prepared solutions when administered into glabellar lines. This underscores that you can store your solution for an extended period without fearing adverse effects.
However, a crucial caveat is that for the best results, reconstituted solutions should be refrigerated at +4°C. A dedicated medical refrigerator ensures this can be easily accomplished. To further enhance the refrigeration of your Botox solutions, ensure stable and uninterrupted power for your refrigerator.
Read More : How Long Does It Take To See Results From Botox
A Solution for Botox Refrigeration: Backup Power
Our Medi-Products refrigerator battery backup systems provide the assurance that your Botox solutions will remain refrigerated at constant temperatures. In the face of unpredictable power outages that threaten the cold storage requirements of medical facilities, having an emergency backup power supply for medical refrigerators becomes imperative.
Our custom-built units are designed to meet your battery backup needs for medical equipment, and they are effortless to install, requiring no maintenance. Reach out to us today to discover how our battery backup systems can best serve you.
